To combat these extensively resistant strain of tuberculosis new antibiotics need to be synthesized and regulated so they do not lose their effectiveness. Research is being done that is looking for ways to develop new antibiotics, utilize natural products known to have antibiotic properties or alter preexisting antibiotics. One of these natural products is Wollamide B (Figure 7), which has recently been isolated from the semiarid soil near Wollogorang Station, Queensland, Australia.7 The larger family, known as the Desotamides are active against growth of gram positive bacteria. Wollamide B is active against mycobacteria and shows promise in treatment of tuberculosis. Wollamide B shows no cytotoxic effects in microscopic observation of the macrophage7. The synthesis of this natural product when completed will allow for analogues of Wollamide B to be tested to determine potential reactivity against Mycobacterium tuberculosis and other gram positive bacteria