This study aimed to determine how resilience and mindfulness can mediate the degree to which the nocebo effect can alter our pain perception and experience. To assess pain perception, the cold pressor task was used to elicit pain while a 100-mm visual analogue scale was used by participants to subjectively rate their pain after their time in the cold water. The Mindful Attention Awareness Scale (MAAS) was used to measure mindfulness. The Connor-Davidson Resilience Scale was used to measure resilience. The main findings showed that (1) mindfulness and resilience have a significant positive correlation, (2) participants with higher mindfulness and resilience did not result in decreased pain ratings compared to those with lower mindfulness and resilience in the baseline trial with no intervention, and (3) participants with higher mindfulness and resilience saw lessened nocebo effects and significantly decreased pain ratings compared to those with lower mindfulness and resilience in the nocebo trials. It was concluded that increased mindfulness and resilience can foster decreased pain perceptions and an increased ability to handle pain, especially when facing nocebo-like effects. Regardless of negative contexts or conditions, it appears as though if one’s innate inner-self is secured by trait mindfulness and resilience they could almost avoid the nocebo effect.