Known molecular rotors are already being used, but there are flaws that do not make these rotors universal. It is necessary to study how they are currently being used and how well they are performing their tasks. Molecular rotors are being used to study proteins: from their expression levels to their degradation in live cells. Old techniques of fluorescent probes were not very desirable because it was an irreversible process. Using a molecular rotor to track the proteins’ function is no longer irreversible because the rotor can be controlled. A molecular rotor, that has fluorescence that can be turned on or off would be able to detect more than before. Previous probes could only detect protein expression level and activity. The use of molecular rotors, over other fluorescent probes, can lead to the detection of protein degradation, translocation, and inhibition. In order for molecular rotors to be included in cells to detect these protein levels, they must be cell permeable.