The purpose of this study is to explore the efficacy of two common over-the-counter medications (acetaminophen and ibuprofen) used to treat delayed-onset muscle soreness. Many studies have been done to test the efficacy of opioids and other controlled substances on muscle trauma and injury. In this study subjects were put through an eccentric dumbbell protocol using half of the subjects’ 1RM, and asked to rate their perceived pain using a visual analog scale and given either a maximal over-the-counter dose of either acetaminophen or ibuprofen. The subjects had their range of motion measured with a goniometer. Each of these measurements were collected every 12 hours until 72 hours after the protocol was ended. Subjects given ibuprofen reported lower pain ratings than subjects who received acetaminophen as treatment. Subjects who received ibuprofen also had a greater range of motion than subjects who received acetaminophen as treatment.